Gruesome video raises concerns about Syria rebels

























BEIRUT (AP) — A video that appears to show a unit of Syrian rebels kicking terrified, captured soldiers and then executing them with machine guns raised concerns Friday about rebel brutality at a time when the United States is making its strongest push yet to forge an opposition movement it can work with.


U.N. officials and human rights groups believe President Bashar Assad‘s regime is responsible for the bulk of suspected war crimes in Syria‘s 19-month-old conflict, which began as a largely peaceful uprising but has transformed into a brutal civil war.





















But investigators of human rights abuses say rebel atrocities are on the rise.


At this stage “there may not be anybody with entirely clean hands,” Suzanne Nossel, head of the rights group Amnesty International, told The Associated Press.


The U.S. has called for a major leadership shakeup of Syria’s political opposition during a crucial conference next week in Qatar. Washington and its allies have been reluctant to give stronger backing to the largely Turkey-based opposition, viewing it as ineffective, fractured and out of touch with fighters trying to topple Assad.


But the new video adds to growing concerns about those fighters and could complicate Washington’s efforts to decide which of the myriad of opposition groups to support. The video can be seen at http://bit.ly/YxDcWE .


“We condemn human rights violations by any party,” U.S. State Department spokeswoman Victoria Nuland said, commenting on the video. “Anyone committing atrocities should be held to account.”


She said the Free Syrian Army has urged its fighters to adhere to a code of conduct it established in August, reflecting international rules of war.


The summary execution of the captured soldiers, purportedly shown in an amateur video, took place Thursday during a rebel assault on the strategic northern town of Saraqeb, said the Britain-based Syrian Observatory for Human Rights, an activist group.


It was unclear which rebel faction was involved, though the al-Qaida-inspired Jabhat al-Nusra was among those fighting in the area, the Observatory said.


The video, posted on YouTube, shows a crowd of gunmen in what appears to be a building under construction. They surround a group of captured men on the ground, some on their bellies as if ordered to lie down, others sprawled as if wounded. Some of the captives are in Syrian military uniforms.


“These are Assad’s dogs,” one of the gunmen is heard saying of those cowering on the ground.


The gunmen kick and beat some of the men. One gunman shouts, “Damn you!” The exact number of soldiers in the video is not clear, but there appear to be about 10 of them.


Moments later, gunfire erupts for about 35 seconds, screams are heard and the men on the floor are seen shaking and twitching. The spray of bullets kicks up dust from the ground.


The video’s title says it shows dead and captive soldiers at the Hmeisho checkpoint. The Observatory said 12 soldiers were killed Thursday at the checkpoint, one of three regime positions near Saraqeb attacked by the rebels in the area that day.


Amnesty International’s forensics analysts did not detect signs of forgery in the video, according to Nossel. The group has not yet been able to confirm the location, date and the identity of those shown in the footage, she said.


After their assault Thursday, rebels took full control of Saraqeb, a strategic position on the main highway linking Syria’s largest city, Aleppo — which rebels have been trying to capture for months — with the regime stronghold of Latakia on the Mediterranean coast.


On Friday, at least 143 people, including 48 government soldiers, were killed in gunbattles, regime shelling attacks on rebel-held areas and other violence, the Observatory said.


Of the more than 36,000 killed so far in Syria, about one-fourth are regime soldiers, according to the Observatory. The rest include civilians and rebel fighters, but the group does not offer a breakdown.


Daily casualties have been rising since early summer, when the regime began bombing densely populated areas from the air in an attempt to dislodge rebels and break a battlefield stalemate.


Karen Abu Zayd, a member of the U.N. panel documenting war crimes in Syria, said the regime is to blame for the bulk of the atrocities so far, but that rebel abuses are on the rise as the insurgents become better armed and as foreign fighters with radical agendas increasingly join their ranks.


“The balance is changing somewhat,” she said in a phone interview, blaming in part the influx of foreign fighters not restrained by social ties that bind Syrians.


Abu Zayd said the panel, though unable to enter Syria for now, has evidence of “at least dozens, but probably hundreds” of war crimes, based on some 1,100 interviews. The group has already compiled two lists of suspected perpetrators and units for future prosecution, she said.


Many rebel groups operate independently, even if they nominally fall under the umbrella of the Free Syrian Army. In recent months, rebel groups have formed military councils to improve coordination, but the chaos of the war has allowed for considerable autonomy at the local level.


“The killing of unarmed soldiers shows how difficult it is to control the escalation of the conflict and establish a united armed opposition that abides by the same ground rules and norms in battle,” said Anthony Skinner, an analyst at Maplecroft, a British risk analysis company.


Rebel commanders and Syrian opposition leaders have promised human rights groups that they would try to prevent abuses. However, New York-based Human Rights Watch said in a report in September that statements by some opposition leaders indicate they tolerate or condone extrajudicial killings.


Free Syrian Army commanders contacted by the AP on Friday said they were either unaware or had no accurate details about the latest video.


Ausama Monajed, a member of the Syrian National Council, the main opposition group in exile, called for the gunmen shown in the video to be tracked down and brought to justice.


He added, however, that atrocities committed by rebels are relatively rare compared to what he said was a “massive genocide by the regime.”


Regime forces have launched indiscriminate attacks on residential neighborhoods with tank shells, mortar rounds and bombs dropped from warplanes, devastating large areas. In raids of rebel strongholds, Assad’s forces have carried out summary executions, rights groups say.


Rebels have also targeted civilians, setting off car bombs near mosques, restaurants and government offices. Human Rights Watch said in September it collected evidence of the summary executions of more than a dozen people by rebels.


In August, a video showed several bloodied prisoners being led into a noisy outdoor crowd in the northern city of Aleppo and placed against a wall before gunmen shot them to death. That video sparked international condemnation, including a rare rebuke from the Obama administration.


The latest video emerged on the eve of a crucial opposition conference that is to begin Sunday in Qatar’s capital of Doha. More than 400 delegates from the Syrian National Council and other opposition groups are expected to attend to choose a new leadership.


U.S. Secretary of State Hillary Rodham Clinton has called for a more unified and representative opposition, even suggesting the U.S. would handpick some of the candidates.


Clinton’s comments reflected growing U.S. impatience with the Syrian opposition, which, in turn, has accused Washington of not having charted a clear path to bringing down Assad.


The Syrian National Council plans to elect new leaders during the four-day conference but is cool to a U.S. proposal to set up a much broader group and a transitional government, said Monajed, the SNC member who runs a think tank in Britain.


U.S. officials have said Washington is pushing for a greater role for the Free Syrian Army and representation of local coordinating committees and mayors of liberated cities in Syria.


Nuland said that it would be easier for the international community to deliver humanitarian assistance to civilians and non-lethal aid to the rebels once a broader, unified opposition leadership is in place.


Such a body could also help persuade Assad backers Russia and China “that change is necessary” and that Syria’s opposition has a better plan for the country than the regime, she said.


___


Associated Press writer Matthew Lee in Washington contributed to this report.


Middle East News Headlines – Yahoo! News



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Google’s Android software in 3 out of 4 smartphones

























SAN FRANCISCO (Reuters) – Three out of every four smartphones sold in the third quarter featured Google Inc‘s Android mobile operating system, as the gap between Google and Apple Inc-based phones widened further, according to a new research report.


Shipments of Android-based smartphones made by Samsung, HTC and other vendors nearly doubled in the third quarter, reaching 136 million units, according to industry research firm IDC. The strong sales boosted Android‘s share of the worldwide smartphone market to 75 percent, from 57.5 percent in the year-ago period.





















Apple‘s share of the market increased to 14.9 percent during the third quarter, from 13.8 percent a year earlier. Apple’s iPhone uses the company’s iOS mobile software.


While Android pulled further ahead of Apple’s iOS, its gains have come mainly at the expense of rival operating systems Blackberry and Symbian, with shipments of phones running those systems declining significantly.


IDC analyst Kevin Restivo cited Android’s close “tie-ins” to Google’s broad array of online services, which include online search and maps, as an important asset that has helped Android grow.


“Google has a thriving, multi-faceted product portfolio. Many of its competitors, with weaker tie-ins to the mobile OS, do not,” Restivo said in the IDC report, which was released on Thursday.


Google offers its Android operating system free to phone manufacturers, and primarily makes money from online advertising when consumers access its services on the devices.


Research in Motion’s Blackberry operating system had 7.7 percent share in the third quarter, compared with 9.5 percent a year earlier.


Symbian, which had 14.6 percent share a year ago, had a 4.1 percent share in the third quarter. Smartphone maker Nokia still offers the Symbian software in some of its phones, but the company has largely shifted to Microsoft Corp’s software.


Mobile versions of Microsoft’s software accounted for 3.6 percent of the smartphone market in the third quarter. But IDC said that the recent launch of the new Microsoft Phone 8 operating system could improve its position in the fast-growing market.


(Reporting By Alexei Oreskovic; Editing by Steve Orlofsky)


Tech News Headlines – Yahoo! News



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“The Man with the Iron Fists” review: RZA serves up half-baked chop-socky

























LOS ANGELES (TheWrap.com) – Homage is a tricky thing – you can be full of love for the object of your tribute, and recreate its trappings with accuracy and sincerity, but that doesn’t mean your results will match the original.


Take “The Man with the Iron Fists,” the first film directed by RZA, founding father of legendary hip-hop combo the Wu-Tang Clan. From the name of his group to the look of his movie, this is a guy who has clearly watched a whole lot of vintage martial-arts movies. If I were on “Who Wants to Be a Millionaire?” and my multiple-choice answers were down to “Five Deadly Venoms” and “The 36th Chamber of Shaolin,” this is the guy I’d want for my lifeline.





















I’d even hire him to create one of those fake trailers in “Grindhouse,” since he clearly appreciates the pacing and the acting style of the Shaw Brothers kung fu classics of the 1970s. Instead, RZA hooked up with “Grindhouse”-meisters Eli Roth (who co-wrote “Fists”) and Quentin Tarantino (who “presents” this new film) to create this full-on, feature-length homage.


The blood spurts, the knives shoot out, and the fists fly – but “The Man with the Iron Fists” never takes off. As the old saying goes, RZA knows the words, but he doesn’t know the music.


He’s also not actor enough to tackle the pivotal role he’s given himself, as Blacksmith in Jungle Village, a tiny hamlet beset by various warring clans. Blacksmith just wants to liberate his lover Lady Silk (Jamie Chung) from the brothel owned by Madam Blossom (Lucy Liu), but instead he must forge weapons for members of the Lion and Fox clans.


The Lions have problems of their own – engaged by the emperor to protect a shipment of gold, second-in-command Silver Lion (Byron Mann) assassinates Gold Lion (Kuan Tai Chen) with the intent of stealing the gold. Word of his treachery reaches Gold Lion’s son Zen Yi (Rick Yune), who returns to Jungle Village seeking vengeance.


Meanwhile, mysterious Englishman Jack Knife (Russell Crowe) shows up at Madam Blossom‘s with a vast array of appetites – and an even more varied collection of weapons.


Word is that RZA originally had a four-hour cut that he hoped to release in two parts, “Kill Bill”-style, but instead was forced to slash his vision down to 90 minutes. That might excuse the choppiness of the plot and exposition, but it doesn’t explain why the fighting scenes are so listless and the acting (with the notable exception of Liu and Crowe, who were smart enough to create their own amusement) so stiff.


Regarding the latter, the performances aren’t even bad in an homage-to-the-bad-acting-of-the-original way; they’re just dull and not ironically so. As for the action sequences, the choreography and camera movements suggest 1970s chop-socky, but they are simulacra under glass — it’s like watching a bad high school production of “West Side Story,” where the Jets and the Sharks are clearly never going to hurt each other.


(The midnight audience that watched the film with me didn’t whoop or laugh a single time during these gory but bloodless melees.)


The one fresh idea that “The Man with the Iron Fists” has – namely, to contrast the 18th century settings with contemporary hip-hop music – is quickly abandoned; after the first one or two fight scenes, we’re back to very generic scoring. The film also might have scored points for allowing the African-American Blacksmith character to exist in feudal China without explaining how he got there…but no, they explain it, in a tedious flashback that adds little except an all-too-brief cameo by an exploitation legend.


If RZA wanted to host a retrospective of kung fu classics, I’d be first in line. But his admiration for the genre doesn’t translate into capably executing it himself.


Movies News Headlines – Yahoo! News



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UK cost agency backs melanoma drugs after price cuts

























LONDON (Reuters) – Two new drugs for skin cancer have been recommended for use on Britain’s state-run health service after the rival manufacturers – Roche and Bristol-Myers Squibb – agreed to cut their prices.


The move underscores the growing pressure on drug companies to cut deals with austerity-hit European governments in order to prove their expensive new medicines offer value for money.





















The National Institute for Health and Clinical Excellence (NICE) said on Friday it had issued final draft guidance recommending both Roche’s Zelboraf and Bristol‘s Yervoy after the companies offered undisclosed discounts.


NICE, which determines if products should be used by the National Health Service (NHS), had initially rejected both medicines, despite acknowledging that they represented a breakthrough in treating melanoma.


The list price for Zelboraf, which is only suitable for patients with a particular genetic profile, is 52,500 pounds ($ 84,600) for an average treatment span of seven months.


The price of a four-dose course of Yervoy, which is recommended only for people who have received prior chemotherapy, is 75,000 pounds.


($ 1 = 0.6207 British pounds)


(Reporting by Ben Hirschler; Editing by Mark Potter)


Medications/Drugs News Headlines – Yahoo! News



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Hey, Gov. Christie: Don’t Rebuild in Harm’s Way

























New Jersey Governor Chris Christie, usually a tireless advocate of individual responsibility and self-reliance, has been sending a different message since Hurricane Sandy devastated the Jersey Shore. Now he’s emphasizing a “we’re all in this together” message as he seeks support from his new best friend, President Barack Obama.


Christie wants the federal government—i.e., taxpayers in other parts of the country—to help rebuild the Jersey Shore back to the way it was before Sandy hit. That could be not only hugely expensive, but wasteful as well—because the next big storm could quickly wipe out the investment.





















New Jersey’s barrier beaches are really nothing more than glorified sand bars. They’ve shifted shoreward about a mile since Colonial times. Trying to stop the force of nature is, in the long run, futile. “The definition of insanity is doing the same thing over and over again and expecting different outcomes,” says Jeffrey Tittel, director of the New Jersey chapter of the Sierra Club.


Christie has gained a national reputation for fiscal discipline that’s led to talk that he could be the Republican nominee in the 2016 presidential election. But if Christie pushes too hard for federal reconstruction funds, he risks losing his reputation for stand-up frugality. “The people who oppose government the most want the bailouts the most,” observes Tittel, speaking of both Christie and his supporters among shore residents and vacationers.


It’s right and decent for the nation as a whole to supply emergency assistance to the hard-hit communities that line the New Jersey coast. Their pain is real. The question is what happens after the emergency is over and it’s time to plan. Christie has one idea. In a briefing for the media, he said, “I don’t believe in a state like ours, where the Jersey Shore is such a part of life, that you just pick up and walk away.” He also said the government should not decide where building is and is not allowed.


That bravado rings hollow, though, when you stop to consider that Christie is hoping to put other people’s money at risk. Matthew Kahn, a professor at the UCLA Anderson School of Management, asks in a newly posted video: “What if New Jersey had to spend its own money for rebuilding New Jersey? It would build a more robust, resilient New Jersey with fewer people living near the coast.” Adds Kahn: “You take more risk when you are implicitly insured. When you spend your own money and you know you’re on the hook for any damage that occurs, you take more precautions.”


In other words, let the free market work. Shore residents are entitled not only to federal disaster aid that pays for rebuilding such critical infrastructure as roads, water lines, and sewer lines, but also to subsidized flood insurance. If they had to pay for the real cost of insurance from the private market, their premiums would be much higher—so much higher that many would decide a safe little cottage in the Poconos might be a better bet. Taxpayers in South Dakota would be spared having to bail out the Jersey Shore again and again.


Christie is right about one thing: Too many people have too much invested in the Jersey Shore to abruptly abandon the whole area to the seagulls. “The Jersey Shore is integral to our identity, and we have a $ 38 billion tourism economy. A significant portion of that is fueled by our shore,” says Lawrence Hajna, a spokesman for the state’s Department of Environmental Protection.


But at a minimum, Christie shouldn’t be luring more people and more investment into harm’s way by protecting shoreline residents through state and federal aid for rebuilt roads, water and sewer lines, and beach restoration. From fiscal years 2009 through 2012, the Army Corps of Engineers spent $ 436 million on replenishing the sand on beaches. Of that, New Jersey was the No. 1 recipient, with 27 percent of the haul, edging out Florida, according to statistics compiled by Howard Marlowe, a lobbyist who helps beach towns get restoration aid.


Much of that costly sand has now been washed out to sea, although some should filter back with the tides over the coming months. Environmentalists like Tittel argue that the money would have been better spent on helping people put their houses up on stilts—or moving out of harm’s way entirely.


New Jersey’s problem is a national problem. Even as climate change increases the severity of storms, the exposure along the nation’s coasts keeps increasing. A storm that would have wiped out a handful of fishermen’s shacks a few generations ago now takes out million-dollar homes. According to the U.S. Census Bureau, the nation’s coastal population grew by 40 million, or 84 percent, from 1960 to 2008.


New Jersey has a Coastal Blue Acres program that acquires land that’s vulnerable to storm damage. But it’s lightly funded, with only $ 15 million for coastal acquisition under a 1995 bond act. Overall, New Jersey ranks in the bottom five for smart response to coastal erosion, according to the nonprofit Surfrider Foundation, along with Alaska, California, Louisiana, and Puerto Rico.


Beach replenishment is an example of throwing good money after bad. Marlowe, the sand lobbyist, argues that it’s a good investment. The Army Corps of Engineers, he says, only does projects that cost less than the savings in terms of property that’s protected from harm by wide beaches and dunes. That could well be true. But it begs the question of why the property needing protection is there in the first place. “I’m not going to deny there are people living in hazardous places,” says Marlowe.


Chris Christie should think back to a lesson he undoubtedly learned as a child with a shovel and pail. Go ahead and build a beautiful sand castle on the beach. Just don’t expect anyone else to protect it for you when the tide comes in.


Businessweek.com — Top News



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‘Assassin’s Creed’ stumbles on PlayStation Vita

























There’s never been a video game heroine quite like Aveline de Grandpre.


The daughter of an African slave and a French shipping magnate in New Orleans at the end of French and Indian War, Aveline is the deadly but charming protagonist of “Assassin’s Creed III: Liberation” (Ubisoft, for the PlayStation Vita, $ 39.99). She seeks to fight injustice in and around the Big Easy as a member of the series’ secret order of assassins.





















The hallmarks of the “Assassin’s Creed” franchise are all gloriously present here in hand-held form: traipsing across a jagged cityscape, dispatching foes with stealthy prowess and plotting against the clandestine group known as the Templars. “Liberation” doesn’t feel like a typical PlayStation Vita game — and that’s both its biggest strength and weakness.


Despite its name, there’s only a tenuous connection to “Assassin’s Creed III,” its sweeping console counterpart. That shouldn’t deter die-hard “Assassin’s Creed” fans from embodying Aveline, who’s armed with iconic hidden blades just like forerunners Altair and Ezio, as well as her own original weapons, such as a blowgun and a parasol loaded with poison darts.


Unlike her male predecessors, Aveline assumes different personas to achieve her aims. As an assassin, she can use all weapons and scale buildings; disguised as a slave, she can blend in with crowds and incite riots; and when dressed as a noble lady, she can awkwardly woo men. It’s an inventive touch, but one that frustratingly makes Aveline always feel handicapped.


Most of “Liberation” takes place in New Orleans, beginning in 1768 as a French colony through the American Revolution. For the most part, the game’s story, setting, combat and characters all work remarkably well given the constraints of the platform, and there’s a plethora of side quests, business pursuits and a multiplayer mode to keep things interesting.


With missions focusing on freeing slaves and rioting against Spanish soldiers, “Liberation” doesn’t shy away from the harsh realities of American history in the South. It’s refreshing to see a video game deal with such serious issues while maintaining a sense of adventure. That alone should be enough for Vita owners to give this historical action title a try.


Unfortunately, “Liberation” is too big for its britches. It’s difficult not to wonder how more effective the game could have been if the developers didn’t bend over backward in an effort to replicate the console experience, especially after playing through a smaller section of “Liberation” that’s set outside Louisiana and ultimately proved to be more fun.


The lamest part of “Liberation” is definitely the most unnecessary, namely, using the Vita’s unique control scheme for actions like opening letters by swiping both touchscreens or revealing secret maps by pointing the rear camera toward a bright light. Such novel gimmicks wouldn’t be so disastrous if they consistently worked and weren’t repeated several times.


There are other glitches, too. Some wobbly graphics, disappearing characters, audio dropouts and other assorted bugs mark “Liberation” as a less polished “Assassin’s Creed” experience. Despite the game’s very daring ambitions, Aveline — and “Assassin’s Creed” fans — deserve more than “Liberation” is able to truly deliver on the Vita. Two stars out of four.


___


Online:


http://assassinscreed.ubi.com/


___


Follow AP Entertainment Writer Derrik J. Lang on Twitter at http://www.twitter.com/derrikjlang .


Gaming News Headlines – Yahoo! News



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Judge throws out lawsuit against Britney Spears and parents

























LOS ANGELES (Reuters) – A Los Angeles judge on Thursday dismissed a lawsuit by the one-time confidante of pop star Britney Spears, ruling there was insufficient evidence to go forward with the trial on allegations of defamation, assault and breach of contract.


“I really thought long and hard. It’s the right thing to do, so I am going to do it,” Los Angeles Superior Court Judge Suzanne Bruguera said, announcing her decision to throw out the case after hearing two weeks of evidence in the civil trial.





















Bruguera’s ruling was a major victory for Spears and her family, despite damaging and sometimes humiliating testimony that lifted the lid on the singer’s controversial career and personal meltdown five years ago.


Sam Lutfi, the self-styled manager of the pop star for a brief period in 2007 and early 2008, had sued Spears’ mother, Lynne Spears, for defaming him in her 2008 book “Through the Storm.” Lynne Spears wrote that Lutfi controlled her daughter, cut her telephone lines and tried to cut the star off from her family.


Bruguera also dismissed claims filed by Lutfi against Spears. He said the singer hired him as her manager after they met in a nightclub in 2007, and he was entitled to a portion of her earnings.


Lutfi case against Spears’ father, Jamie Spears, was also thrown out. Lutfi alleged that Jamie Spears punched him in 2008 while the singer was in a Los Angeles psychiatric ward.


Lutfi, 38, said he would appeal the ruling.


Spears, 30, has since staged a comeback with world tours, hit albums and a new job as judge on Fox’s TV talent show “The X-Factor.” She did not attend the trial.


In testimony last week, Lutfi sobbed on the witness stand, saying he received death threats because of the villainous portrayal of him in the book. He also claimed he tried to get Spears off drugs and protect her from paparazzi photographers who hounded her day and night.


His most sensational claim was that Spears shaved her head in February 2007 because she feared her hair could be tested for drug use in her bitter child custody battle with ex-husband Kevin Federline.


Lutfi also told the court that he brought drug-sniffing dogs to her home and flushed a bag of white powder down the toilet.


Jamie Spears’ attorney told the court that his client was afraid that his daughter would die from drug abuse and believed that Lutfi was making her problems worse.


Lynne Spears testified that Lutfi crushed up drugs and put them into the singer’s food to help her sleep.


Spears’ meltdown led to her father’s conservatorship, which gives him legal control over her finances and health.


(Editing by Jill Serjeant and Stacey Joyce)


Music News Headlines – Yahoo! News



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Sanofi draws fire over cost of MS drug Lemtrada

























PARIS (Reuters) – Medical journal The Lancet warned that Sanofi‘s experimental multiple sclerosis drug Lemtrada may be too costly for patients and health insurers once it gets approved by regulators.


The journal, which published the encouraging results of two late-stage Lemtrada tests on Thursday, also criticized the drugmaker’s decision to withdraw leukemia therapy Campath, the same drug given at a different dosage, depriving MS patients who had been using it off-label.





















In an editorial accompanying the test results, The Lancet voiced concerns that Lemtrada would be priced higher than current MS drugs on the market and said the discontinuation of Campath may mean patients who had used it for MS would not be able to continue their treatment.


The injectable drug, chemically known as alemtuzumab, was sold until September 2012 under the name Campath as treatment for leukemia and given more frequently at a higher dosage.


“There is concern that with a license for multiple sclerosis, the cost of alemtuzumab could rise and might become too expensive for many patients and health systems,” the editorial said.


Although Campath remains available free of charge to leukemia patients, Sanofi’s rare disease unit Genzyme pulled it off the market in September to prevent its unauthorized use as an MS drug.


Analysts said the move would allow the company to adjust the price to match that of rival MS drugs on the market.


A full course of Campath, which in 2011 had sales of $ 76 million, cost around $ 60,000 when given three times a week for up to 12 weeks, according to Genzyme.


Lemtrada, instead, is given at less than half the dose of Campath for 5 consecutive days and then again for 3 days a year later. Since the drug has yet to be approved, it remains unclear how much Sanofi will charge for it.


The drug, which works by resetting a person’s immune system, has shown in late-stage trials to be an effective treatment for MS patients who have failed to respond to other therapies.


It has also shown to benefit people not previously treated for the disease, suggesting it could be used as a first-line MS therapy.


But patients need regular monitoring for serious side effects that can include infections and autoimmune diseases.


“It’s important that the appropriate safety monitoring is in place for patients who are prescribed Lemtrada,” Genzyme’s head of MS, Bill Sibold, told Reuters, responding to questions about the Lancet editorial. “Until an approved risk-management program is established, we believe the use of Lemtrada should only occur in clinical trials.”


Lemtrada remains available to patients who are taking part in clinical tests.


Sibold declined to discuss pricing plans for Lemtrada, but said Genzyme has set up programs to make its approved drugs available to patients who cannot afford them. “With Lemtrada it would be no different,” he said.


DRUG FUNDING


But there are concerns that cash-strapped European governments may balk at funding the drug through their public healthcare systems.


Doug Brown, Head of Biomedical Research at U.K. charity MS Society said that while Lemtrada’s results are great news for patients, the drug would only be useful to them if it were available through the country’s publicly funded National Health Service.


“We urge Genzyme to price the treatment responsibly so that if it’s licensed, it’s deemed cost effective on the NHS,” he said.


The U.K.’s cost-effectiveness body National Institute for Health and Clinical Excellence (NICE), whose opinions are also watched closely in other countries, initially rejected Novartis’ MS pill Gilenya, only to make a U-turn after the company agreed to a discounted price.


Sanofi launched its MS pill Aubagio in the U.S. at a price of $ 45,000 for a year’s treatment, making it cheaper than rivals.


Gilenya – the only other MS pill currently on the market – costs 28 percent more, while injectable treatments such as Biogen Idec Inc’s Avonex and Teva Pharmaceutical Industries Ltd’s Copaxone are 8 and 6.5 percent higher respectively.


(Reporting by Elena Berton; Editing by Tim Dobbyn)


Medications/Drugs News Headlines – Yahoo! News



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New York state asks Washington to cover all storm costs

























NEW YORK/WASHINGTON (Reuters) – New York state on Wednesday asked the U.S. federal government to pay all the costs of cleaning up and repairing damage from massive storm Sandy that tore through the Northeast this week and crippled New York City.


Governor Andrew Cuomo said he is asking fellow Democrat, President Barack Obama, to pay 100 percent of the estimated $ 6 billion bill, at a time that state and local government budgets remain constrained by a weak economic recovery.





















That would be a significant change from last year when the federal government covered about 75 percent of the $ 1.2 billion cost paid by New York to clean up after storm Irene hit the region.


The two U.S. senators from neighboring New Jersey, the other state hit hardest by the storm, also asked that the federal government cover more than the usual share of the cost, given the size of the disaster and the financially strapped local coffers.


“Recent storms in New Jersey have already placed a significant burden on our state and local governments, which have been forced to pay for disaster response and will need federal assistance for recovery from Hurricane Sandy,” Senator Frank Lautenberg and Senator Robert Menendez, both Democrats, wrote in a letter to Obama.


“While we understand the federal share is typically 75 percent of these total costs, the unprecedented and extraordinary extent of damage Hurricane Sandy has caused to our state merits an adjustment to this cost-share to 90 to 100 percent federal coverage,” the two senators said.


New Jersey Governor Chris Christie, a Republican, did not reply to request of comments.


Obama and Christie toured storm-stricken parts of New Jersey on Wednesday, taking in scenes of flooded roads from the air and telling residents they were moving quickly to get them help.


‘WE CAN’T PRINT MONEY’


New York top finance official, Comptroller Thomas DiNapoli, said Washington should foot the bill, because of lingering financial pressures on state and local governments from the 2007-09 recession.


“I think the focus will have to be on Washington, for obvious reasons,” DiNapoli told Reuters in an interview.


“They have greater resources. They can print money; we can’t do that here. And given the fact this is not just a New York disaster, it’s really a national disaster, it’s probably for the federal government to step up and play a significant role.”


“The problem is the state is limited in its resource capacity. We just put out the mid-year report a week or two ago and it really showed tax revenues are down,” DiNapoli said.


Most U.S. states must balance their budgets, unlike the federal government, and it is up to Obama to decide if federal funds can cover all the costs.


“The president has the discretion to go higher. Seventy-five percent is a floor not a ceiling,” said Matt Mayer, a former senior official at the Department of Homeland Security.


If Obama accepts covering all the costs, this would be announced by Federal Emergency management Agency, Mayer said.


Former President George W. Bush allowed 100 percent reimbursement of costs in some states after Hurricane Katrina struck in 2005, Mayer, who worked at DHS during Bush’s presidency, told Reuters.


Cuomo said in a letter to Obama that “initial estimates project up to $ 6 billion in lost economic revenue in the greater metropolitan area and the state” due to disruption to business in the world’s financial hub.


Cuomo added that “the significant impact from Hurricane Sandy plainly warrants providing this assistance.”


The state, he said, was still battling multi-building fires, tunnel closures, and power outages at hospitals and other vital facilities. Plus there are destroyed homes and people needing shelter.


“Moreover, the cost to restore the complex electrically driven subway and rail transportation systems after total inundation from saltwater flooding will place a tremendous financial burden on New York state,” Cuomo said in the letter.


In New York alone nearly 2 million homes and businesses are still without power.


Cuomo said federal support is key to making sure state and local governments can respond effectively to the disaster.


New York state is rated AA by Standard and Poor’s and Aa2 by Moody’s and its outstanding debt is the second highest among states, after California.


(Additional reporting by Michael Connor in Miami; writing by Tiziana Barghini in New York; Editing by Mary Milliken and Bob Burgdorfer)


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Clinton calls for overhaul of Syrian opposition

























ZAGREB (Reuters) – The United States called on Wednesday for an overhaul of Syria‘s opposition leadership, saying it was time to move beyond the Syrian National Council and bring in those “in the front lines fighting and dying”.


Secretary of State Hillary Clinton, signaling a more active stance by Washington in attempts to form a credible political opposition to Syrian President Bashar al-Assad, said a meeting next week in Qatar would be an opportunity to broaden the coalition against him.





















“This cannot be an opposition represented by people who have many good attributes but who, in many instances, have not been inside Syria for 20, 30, 40 years,” she said during a visit to Croatia.


“There has to be a representation of those who are in the front lines fighting and dying today to obtain their freedom.”


Clinton’s comments represented a clear break with the Syrian National Council (SNC), a largely foreign-based group which has been among the most vocal proponents of international intervention in the Syrian conflict.


U.S. officials have privately expressed frustration with the SNC’s inability to come together with a coherent plan and with its lack of traction with the disparate internal groups which have waged the 19-month uprising against Assad’s government.


Senior members of the SNC, Free Syrian Army (FSA) and other rebel groups ended a meeting in Turkey on Wednesday and pledged to unite behind a transitional government in coming months.


“It’s been our divisions that have allowed the Assad forces to reach this point,” Ammar al-Wawi, a rebel commander, told Reuters after the talks outside Istanbul.


“We are united on toppling Assad. Everyone, including all the rebels, will gather under the transitional government.”


Mohammad Al-Haj Ali, a senior Syrian military defector, told a news conference after the meeting: “We are still facing some difficulties between the politicians and different opposition groups and the leaders of the Free Syrian Army on the ground.”


Clinton said it was important that the next rulers of Syria were both inclusive and committed to rejecting extremism.


“There needs to be an opposition that can speak to every segment and every geographic part of Syria. And we also need an opposition that will be on record strongly resisting the efforts by extremists to hijack the Syrian revolution,” she said.


Syria’s revolt has killed an estimated 32,000. A bomb near a Shi’ite shrine in a suburb of Damascus killed at least six more people on Wednesday, state media and opposition activists said.


NEW LEADERSHIP


The meeting next week in Qatar’s capital Doha represents a chance to forge a new leadership, Clinton said, adding the United States had helped to “smuggle out” representatives of internal Syrian opposition groups to a meeting in New York last month to argue their case for inclusion.


“We have recommended names and organizations that we believe should be included in any leadership structure,” she told a news conference.


“We’ve made it clear that the SNC can no longer be viewed as the visible leader of the opposition. They can be part of a larger opposition, but that opposition must include people from inside Syria and others who have a legitimate voice which must be heard.”


The United States and its allies have struggled for months to craft a credible opposition coalition.


U.S. President Barack Obama’s administration has said it is not providing arms to internal opponents of Assad and is limiting its aid to non-lethal humanitarian assistance.


It concedes, however, that some of its allies are providing lethal assistance – a fact that Assad’s chief backer Russia says shows western powers are intent on determining Syria’s future.


Russia and China have blocked three U.N. Security Council resolutions aimed at increasing pressure on the Assad government, leading the United States and its allies to say they could move beyond U.N. structures for their next steps.


Clinton said she regretted but was not surprised by the failure of the latest attempted ceasefire, called by international mediator Lakhdar Brahimi last Friday. Each side blamed the other for breaking the truce.


“The Assad regime did not suspend its use of advanced weaponry against the Syrian people for even one day,” she said.


“While we urge Special Envoy Brahimi to do whatever he can in Moscow and Beijing to convince them to change course and support a stronger U.N. action we cannot and will not wait for that.”


Clinton said the United States would continue to work with partners to increase sanctions on the Assad government and provide humanitarian assistance to those hit by the conflict.


(Additional reporting by Ayla Jean Yackley; editing by Andrew Roche)


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