Roche’s Avastin misses key data point in brain cancer study

ZURICH (Reuters) – Swiss drugmaker Roche’s cancer drug Avastin failed to make a statistically significant difference to survival rates of patients with a common form of brain cancer in a late-stage study, the company said on Saturday.

The Phase III AVAglio study presented at the Society for Neuro-Oncology congress in Washington on Saturday showed Avastin, combined with radiation and chemotherapy, reduced the risk of cancer worsening or death, the Basel-based drugmaker said in a news release.

But the drug did not reach statistical significance in overall survival, a key data point. Further data are expected next year, Roche said.

“The interim results for overall survival (OS), the other co-primary endpoint, did not reach statistical significance,” the company said in the statement.

Earlier data from the study published in August showed Avastin significantly extended progression-free survival of people with an aggressive form of brain cancer.

Avastin is Roche’s third-biggest seller and is approved to treat several types of cancer, including breast, kidney, colorectal and ovarian cancers.

(Reporting by Katharina Bart and Caroline Copley; editing by Jason Webb)

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Polish deputy PM to resign after losing party election

WARSAW (Reuters) – Poland’s Deputy Prime Minister Waldemar Pawlak said he would resign from the government after unexpectedly losing a battle for the leadership of the junior coalition partner on Saturday, but there was no threat to the stability of the coalition.

Janusz Piechocinski, a 52-year-old member of parliament who beat Pawlak by 547 to 530 votes in the election at the PSL congress, said he wanted to keep the coalition with the Civic Platform (PO) intact.

Pawlak, who is also the economy minister in Prime Minister Donald Tusk‘s government, had led the PSL for seven years. Serving twice as a prime minister in the past two decades, he has been PSL’s most prominent politician. He said he would hand his resignation to Tusk on Monday.

“PSL will be a rational coalition partner, a rational and wise participant of the parliamentary debate,” Piechocinski told reporters after the vote, adding he wanted Pawlak to retain his position in government.

“Nothing that happened is a challenge to the government, to the coalition.”

The party hit the headlines in July after media released recordings that showed suspected corruption among its party members. It led to the resignation of Agriculture Minister Marek Sawicki.

PSL members quoted by local media said Piechocinski won largely because of a campaign that targeted delegates from outside Warsaw and other larger cities.

(Reporting by Maciej Onoszko; Editing by Alison Williams)

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Israel hits Hamas buildings, shoots down Tel Aviv-bound rocket

GAZA/JERUSALEM (Reuters) – Israeli aircraft bombed Hamas government buildings in Gaza, and the “Iron Dome” defense system shot down a Tel Aviv-bound rocket on Saturday as Israel geared up for a possible ground invasion.

Hamas, the Palestinian Islamist group that runs the Gaza Strip, said Israeli missiles wrecked the office building of Prime Minister Ismail Haniyeh – where he had met on Friday with the Egyptian prime minister – and struck a police headquarters.

Along the Tel Aviv beachfront, volleyball games came to an abrupt halt and people crouched as sirens sounded. Two interceptor rockets streaked into the sky. A flash and an explosion followed as Iron Dome, deployed only hours earlier near the city, destroyed the incoming projectile in mid-air.

With Israeli tanks and artillery positioned along the Gaza border and no end in sight to hostilities now in their fourth day, Tunisia’s foreign minister travelled to the enclave in a show of Arab solidarity.

In Cairo, a presidential source said Egyptian President Mohamed Mursi would hold four-way talks with the Qatari emir, the prime minister of Turkey and Hamas chief Khaled Meshaal in the Egyptian capital on Saturday to discuss the Gaza crisis.

Egypt has been working to reinstate calm between Israel and Hamas after an informal ceasefire brokered by Cairo unraveled over the past few weeks. Meshaal, who lives in exile, has already held a round of talks with Egyptian security officials.

Officials in Gaza said 43 Palestinians, nearly half of them civilians including eight children, had been killed since Israel began its air strikes. Three Israeli civilians were killed by a rocket on Thursday.

Israel unleashed its massive air campaign on Wednesday with the declared goal of deterring Hamas from launching rockets that have plagued its southern communities for years.

The Israeli army said it had zeroed in on a number of government buildings during the night, including Haniyeh’s office, the Hamas Interior Ministry and a police compound.

Taher al-Nono, a spokesman for the Hamas government, held a news conference near the rubble of the prime minister’s office and pledged: “We will declare victory from here.”

Hamas‘s armed wing claimed responsibility for Saturday’s rocket attack on Tel Aviv, the third against the city since Wednesday. It said it fired an Iranian-designed Fajr-5 at the coastal metropolis, some 70 km (43 miles) north of Gaza.

“Well that wasn’t such a big deal,” said one woman, who had watched the interception while clinging for protection to the trunk of a baby palm tree on a traffic island.

In the Israeli Mediterranean port of Ashdod, a rocket ripped into several balconies. Police said five people were hurt.

Among those killed in airstrikes on Gaza on Saturday were at least four suspected militants riding on motorcycles.

Israel’s operation has drawn Western support for what U.S. and European leaders have called Israel’s right to self-defense, along with appeals to avoid civilian casualties.

Hamas, shunned by the West over its refusal to recognize Israel, says its cross-border attacks have come in response to Israeli strikes against Palestinian fighters in Gaza.

RESERVIST CALL-UP

At a late night session on Friday, Israeli cabinet ministers decided to more than double the current reserve troop quota set for the Gaza offensive to 75,000, political sources said, in a signal Israel was edging closer to an invasion.

Around 16,000 reservists have already been called up.

Asked by reporters whether a ground operation was possible, Major-General Tal Russo, commander of the Israeli forces on the Gaza frontier, said: “Definitely.”

“We have a plan … it will take time. We need to have patience. It won’t be a day or two,” he added.

A possible move into the densely populated Gaza Strip and the risk of major casualties it brings would be a significant gamble for Prime Minister Benjamin Netanyahu, favorite to win a January national election.

Hamas fighters are no match for the Israeli military. The last Gaza war, involving a three-week long Israeli air blitz and ground invasion over the New Year period of 2008-09, killed over 1,400 Palestinians, mostly civilians. Thirteen Israelis died.

But the Gaza conflagration has stirred the pot of a Middle East already boiling from two years of Arab revolution and a civil war in Syria that threatens to spread beyond its borders.

“Israel should understand that many things have changed and that lots of water has run in the Arab river,” Tunisian Foreign Minister Rafik Abdesslem said as he surveyed the wreckage from a bomb-blast site in central Gaza.

One major change has been the election of an Islamist government in Cairo that is allied with Hamas, potentially narrowing Israel’s manoeuvering room in confronting the Palestinian group. Israel and Egypt made peace in 1979.

“DE-ESCALATION”

Netanyahu spoke late on Friday with U.S. President Barack Obama for the second time since the offensive began, the prime minister’s office said in a statement.

“(Netanyahu) expressed his deep appreciation for the U.S. position that Israel has a right to defend itself and thanked him for American aid in purchasing Iron Dome batteries,” the statement added.

The two leaders have had a testy relationship and have been at odds over how to curb Iran’s nuclear program.

A White House official said on Saturday Obama called Turkish Prime Minister Tayyip Erdogan to discuss how the two countries could help bring an end to the Gaza conflict.

Ben Rhodes, White House deputy national security adviser, told reporters that Washington “wants the same thing as the Israelis want”, an end to rocket attacks from Gaza. He said the United States is emphasizing diplomacy and “de-escalation”.

In Berlin, a spokesman for German Chancellor Angela Merkel said she had spoken to Netanyahu and Egypt’s Mursi, stressing to the Israeli leader that Israel had a right to self-defense and that a ceasefire must be agreed as soon as possible to avoid more bloodshed.

U.N. Secretary-General Ban Ki-moon is expected to visit Israel and Egypt next week to push for an end to the fighting in Gaza, U.N. diplomats said on Friday.

The Israeli military said 492 rockets fired from Gaza have hit Israel since the operation began. Iron Dome intercepted another 245.

In Jerusalem, targeted by a Palestinian rocket on Friday for the first time in 42 years, there was little outward sign on the Jewish Sabbath that the attack had any impact on the usually placid pace of life in the holy city.

Some families in Gaza have abandoned their homes – some of them damaged and others situated near potential Israeli targets – and packed into the houses of friends and relatives.

(Additional reporting by Dan Williams and Douglas Hamilton in Tel Aviv, Allyn Fisher-Ilan in Jerusalem, Jeff Mason aboard Air Force One, Writing by Jeffrey Heller; editing by Crispian Balmer)

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Wii U Will Launch With 24 Games This Sunday

Assassin’s Creed III

A version of the latest chapter in the Assassin’s Creed saga, a week after it was released on other console.

Click here to view this gallery.

[More from Mashable: Xbox Live Celebrates 10 Years of Connecting Gamers]

Nintendo’s newest console is out this Sunday, and there are already people lining up outside retailers to get one.

There are 24 games available for the Wii U at launch. Some are highly anticipated Nintendo staples, like New Super Mario Brothers U, and some are interesting and creative titles from third-party developers, like Scribblenauts Unlimited and ZombiU. Many games already out on other systems are being released for the Wii U as well, including Assassin’s Creed III and NBA 2K13; some of these games even have extra functionality that’s been added to take advantage of the Wii U GamePad.

[More from Mashable: Competitive Gaming Seeing TV-Levels of Viewership in 2012]

If you don’t see a game in the gallery above that you thought was coming to the Wii U, it’s because many announced games will be available in the “launch window”, a broad period from now until March. That’s when games like Pikmin 3 and LEGO City Undercover will come out.

If you haven’t preordered a Wii U from a large retailer, many places will still have them available at launch day. Expect long lines at larger retailers though.

Are you planning on purchasing a Wii U this weekend, and what games do you most want to buy? Let us know in the comments.

This story originally published on Mashable here.

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Liam Neeson in negotiations for crime thriller “The All Nighter”

LOS ANGELES (TheWrap.com) – Liam Neeson is in negotiations to star in the crime thriller “The All Nighter (AKA Run All Night)” a person familiar with the situation has told TheWrap.

The story follows an aging hit man who, in order to protect his wife and son, must take on his former boss in a single night. He then winds up on the run from the mob and the authorities with his estranged son.

The film is being produced by Vertigo Entertainment‘s Roy Lee, along with Brooklyn Weaver for Warner Bros. which declined to comment. The studio acquired Brad Ingelsby‘s spec script “The All Nighter” in January for a reported six figure sum.

Neeson’s upcoming films include “Non-Stop” and “A Walk Among The Tombstones.” He will also be featured in a voice role in the upcoming film “Lego: The Piece of Resistance.”

Lee is working on a long-list of projects including Spike Lee’s remake of the South Korean thriller, “Oldboy,” which is currently filming. He is also producing the upcoming thriller “The Double Hour”; a feature film based on the hit video game “Deus-Ex Human Revolution”; “Lego: The Piece of Resistance,” and the action thriller “Sleepless Night,” which is also set up at Warner Bros. Weaver’s credits include “Thirteen” and “Picture Book.”

Ingelsby’s upcoming projects as a writer include “The Raid.” In 2008, he made another major spec deal for his revenge thriller “The Low Dweller,” which went to Relativity Media.

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Five Republican governors reject state-run health markets

WASHINGTON (Reuters) – Five Republican governors rejected on Friday a major provision of President Barack Obama‘s healthcare reform law that calls on states to set up online health insurance markets where consumers can purchase private coverage at federally subsidized rates.

That makes it likely that the federal government will establish its own markets, known as healthcare exchanges, in those states and potentially supplant state control of private individual insurance markets.

But in what could be a sign of thawing relations between administration officials and some state Republican leaders, three of the five governors — representing Ohio, Michigan and Florida — expressed a willingness to work with Washington as reforms inch toward a January 1, 2014, deadline for full operation.

Wisconsin Governor Scott Walker and Georgia Governor Nathan Deal said they would not cooperate at all.

Missouri Governor Jeremiah Nixon, a Democrat, said the state would not run its own exchange but did not take a position on a federal partnership. He said the state legislature could take up the issue early next year.

Meanwhile, Indiana Governor Mitch Daniels, a Republican, deferred to the state’s governor-elect, Mike Pence, also Republican, who has said he intends to oppose both a state-based exchange and a federal partnership after assuming office next year.

The announcements came a day after the U.S. Department of Health and Human Services extended its deadline for states to say whether they would operate their own exchanges. The positions reveal an emerging split between Republican governors who had appeared to form a united front against healthcare reform before Obama’s November 6 reelection ensured the law’s implementation.

Many governors have dragged their feet on implementing the Patient Protection and Affordable Care Act, hoping Republican Mitt Romney would defeat Obama and repeal the law. They are now deciding whether to set up their own exchanges, accept a partnership with the federal government or allow Washington to take control.

“What this reflects is the difficult position of some of these governors,” said Jennifer Tolbert of the nonpartisan Kaiser Family Foundation, which tracks healthcare issues. “While they may oppose the new reform law and its requirements, some also don’t want the federal government to come in and run the exchange and take over that responsibility.”

Friday was the original deadline for states to tell the administration whether they plan to operate their own exchanges and file blueprints to show how they would do it. The administration extended the deadline to December 14 after governors requested more time to comply.

The Affordable Care Act is scheduled to extend health coverage to more than 30 million uninsured Americans beginning January 1, 2014. About half of those would be covered by exchanges, designed to allow working families to purchase coverage at subsidized rates.

A MEETING IN FLORIDA?

At least 17 states already have told the administration that they will create their own exchanges, according to sources familiar with the situation. An HHS spokeswoman could not confirm that number. Experts predicted the total could rise to 20 by the time the new deadline passes.

As many as 15 states from Georgia and Texas to Wyoming and Maine opposed the exchanges outright before the election.

But some of those, including Nebraska, have since opted to work with the federal government on an exchange. Others say they are still deliberating. Over the past week, Kansas has rejected all participation in an exchange while Nebraska has agreed to seek a federal partnership.

States that reject the call for state-run exchanges but opt for a federal partnership could better ensure smooth market operations for residents than states that reject exchanges outright, experts say. They could also have an easier time adopting a state-based operation in coming years.

All five Republican governors who announced their plans on Friday complained that the Obama administration has been slow to release details about how exchanges should operate and complained that the law has proved too inflexible to meet the needs of individual states.

“At this point, based on the information we have, states do not have any flexibility to build and manage exchanges in ways that respond to unique needs of their citizens or markets,” Ohio Governor John Kasich said in a November 16 letter to the Centers for Medicare and Medicaid Services, an HHS agency that is implementing the law’s exchange provision.

“Regardless of who runs the exchange, the end product is the same,” he added.

But Kasich and Michigan Governor Rick Snyder both suggested their positions could change as details emerge.

Florida’s Republican governor, Rick Scott, said in a letter to HHS Secretary Kathleen Sebelius that he could not see how an exchange would improve healthcare access while lowering costs for Florida residents.

But Scott said Florida was willing to “partner” with the administration to find a solution. He invited Sebelius to a meeting to discuss the issues.

States have until February 15, 2013, to say whether they would prefer a federal partnership exchange.

Whatever the choice, Sebelius has pledged that Americans in all 50 states will have access to coverage through exchanges when the Affordable Care Act comes into full force in 2014.

(Reporting by David Morgan; Additional reporting by Karen Pierog; Editing by Leslie Adler and Tim Dobbyn)

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Retailer Comet to close 30 stores

16 November 2012 Last updated at 19:00 ET

The insolvent electrical chain Comet is preparing to close about 30 stores by the end of November, the BBC has learned.

Comet appointed administrators earlier this month, putting 6,611 jobs at risk.

The remaining 206 or so outlets are expected to continue trading over the Christmas period, but their future remains deeply uncertain.

The first of the store closures will begin next week, the Financial Times reported earlier.

The administrators, Deloitte, has already announced 330 job losses at Comet’s headquarters and among administrative staff and there have also been reports that it is preparing to close down the retailer’s home delivery operation.

Comet’s demise was one of the biggest High Street casualties of recent years.

The electricals chain had been hit hard by the drop in consumer spending in the UK since 2008, which has been particularly acute in the case of the big items that Comet sells.

Many of Comet’s customers are first-time home-buyers, according to Deloitte, meaning that business has been hurt by the much tighter conditions in the UK mortgage market.

According to Deloitte, the company had been pushed to the brink by a cash drain caused by suppliers who had been unwilling to provide credit to Comet. Without such credit, the chain was unable to stock-up for Christmas.

Deloitte recently allowed gift vouchers bought by members of the public to be used at stores, days after suspending them, after taking time to “assess the financial position of the company”.

Rival Dixons has offered Christmas jobs to hundreds of Comet staff who face redundancy.

BBC News – Business

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Israel moves on reservists after rockets target cities

GAZA/JERUSALEM (Reuters) – Israeli ministers were on Friday asked to endorse the call-up of up to 75,000 reservists after Palestinian militants nearly hit Jerusalem with a rocket for the first time in decades and fired at Tel Aviv for a second day.

The rocket attacks were a challenge to Israel‘s Gaza offensive and came just hours after Egypt‘s prime minister, denouncing what he described as Israeli aggression, visited the enclave and said Cairo was prepared to mediate.

Israel’s armed forces announced that a highway leading to the Gaza Strip and two roads bordering the enclave would be off-limits to civilian traffic until further notice.

Tanks and self-propelled guns were seen near the border area on Friday, and the military said it had already called 16,000 reservists to active duty.

Prime Minister Benjamin Netanyahu convened senior cabinet ministers in Tel Aviv after the rockets struck to decide on widening the Gaza campaign.

Political sources said ministers were asked to approve the mobilization of up to 75,000 reservists, in what could be preparation for a possible ground operation.

No decision was immediately announced and some commentators speculated in the Israeli media the move could be psychological warfare against Gaza’s Hamas rulers. A quota of 30,000 reservists had been set earlier.

Israel began bombing Gaza on Wednesday with an attack that killed the Hamas military chief. It says its campaign is in response to Hamas missiles fired on its territory. Hamas stepped up rocket attacks in response.

Israeli police said a rocket fired from Gaza landed in the Jerusalem area, outside the city, on Friday.

It was the first Palestinian rocket since 1970 to reach the vicinity of the holy city, which Israel claims as its capital, and was likely to spur an escalation in its three-day old air war against militants in Gaza.

Rockets nearly hit Tel Aviv on Thursday for the first time since Saddam Hussein’s Iraq fired them during the 1991 Gulf War. An air raid siren rang out on Friday when the commercial centre was targeted again. Motorists crouched next to cars, many with their hands protecting their heads, while pedestrians scurried for cover in building stairwells.

The Jerusalem and Tel Aviv strikes have so far caused no casualties or damage, but could be political poison for Netanyahu, a conservative favored to win re-election in January on the strength of his ability to guarantee security.

“The Israel Defence Forces will continue to hit Hamas hard and are prepared to broaden the action inside Gaza,” Netanyahu said before the rocket attacks on the two cities.

Asked about Israel massing forces for a possible Gaza invasion, Hamas spokesman Sami Abu Zuhri said: “The Israelis should be aware of the grave results of such a raid and they should bring their body bags.”

Officials in Gaza said 28 Palestinians had been killed in the enclave since Israel began the air offensive with the declared aim of stemming surges of rocket strikes that have disrupted life in southern Israeli towns.

The Palestinian dead include 12 militants and 16 civilians, among them eight children and a pregnant woman. Three Israelis were killed by a rocket on Thursday. A Hamas source said the Israeli air force launched an attack on the house of Hamas’s commander for southern Gaza which resulted in the death of two civilians, one a child.

SOLIDARITY VISIT

A solidarity visit to Gaza by Egyptian Prime Minister Hisham Kandil, whose Islamist government is allied with Hamas but also party to a 1979 peace treaty with Israel, had appeared to open a tiny window to emergency peace diplomacy.

Kandil said: “Egypt will spare no effort … to stop the aggression and to achieve a truce.”

But a three-hour truce that Israel declared for the duration of Kandil’s visit never took hold. Israel said 66 rockets launched from the Gaza Strip hit its territory on Friday and a further 99 were intercepted by the Iron Dome anti-missile system.

Israel denied Palestinian assertions that its aircraft struck while Kandil was in the enclave.

Israel Radio’s military affairs correspondent said the army’s Homefront Command had told municipal officials to make civil defence preparations for the possibility that fighting could drag on for seven weeks. An Israeli military spokeswoman declined to comment on the report.

The Gaza conflagration has stoked the flames of a Middle East already ablaze with two years of Arab revolution and a civil war in Syria that threatens to leap across borders.

It is the biggest test yet for Egypt’s new President Mohamed Mursi, a veteran Islamist politician from the Muslim Brotherhood who was elected this year after last year’s protests ousted military autocrat Hosni Mubarak.

Egypt’s Muslim Brotherhood are spiritual mentors of Hamas, yet Mursi has also pledged to respect Cairo’s 1979 peace treaty with Israel, seen in the West as the cornerstone of regional security. Egypt and Israel both receive billions of dollars in U.S. military aid to underwrite their treaty.

Mursi has vocally denounced the Israeli military action while promoting Egypt as a mediator, a mission that his prime minister’s visit was intended to further.

A Palestinian official close to Egypt’s mediators told Reuters Kandil’s visit “was the beginning of a process to explore the possibility of reaching a truce. It is early to speak of any details or of how things will evolve”.

Hamas fighters are no match for the Israeli military. The last Gaza war, involving a three-week long Israeli air blitz and ground invasion over the New Year period of 2008-2009, killed more than 1,400 Palestinians, mostly civilians. Thirteen Israelis died.

Tunisia’s foreign minister was due to visit Gaza on Saturday “to provide all political support for Gaza” the spokesman for the Tunisian president, Moncef Marzouki, said in a statement.

The United States asked countries that have contact with Hamas to urge the Islamist movement to stop its rocket attacks.

Hamas refuses to recognize Israel’s right to exist. By contrast, Palestinian President Mahmoud Abbas, who rules in the nearby West Bank, does recognize Israel, but peace talks between the two sides have been frozen since 2010.

Abbas’s supporters say they will push ahead with a plan to have Palestine declared an “observer state” rather than a mere “entity” at the United Nations later this month.

(Additional reporting by Maayan Lubell, Jeffrey Heller and Crispian Balmer in Jerusalem; Writing by Jeffrey Heller; Editing by Giles Elgood)

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TV, movie features on new Wii U delayed until Dec.

NEW YORK (AP) — Some of the entertainment features on Nintendo’s new Wii U won’t be available when the game machine goes on sale Sunday.

Nintendo didn’t give a reason for the delay in Friday’s news release. In a statement, the company said it wanted the service “to be the best possible experience for all consumers.” Nintendo said it was still working to “make it available as soon as possible.”

The new service, Nintendo TVii, promises to take into account all the ways users watch movies, TV shows and sports.

If you like the TV show “Modern Family,” for example, it will present you with a list of the show’s episodes gathered from available sources, whether that’s Hulu, Netflix or traditional cable TV.

The Wii U is the first major game console to launch in six years. The free TVii — pronounced “tee-veeee” — features were supposed to be available at the time of Wii U’s launch in the U.S. and Canada. Nintendo said the TVii service will now be activated sometime in December.

With TVii the GamePad controller that comes with Wii U is supposed to work as a fancy remote control. Viewers will be able to browse shows to watch or send suggestions to other Wii users. The service also captures scenes from live TV and displays them on the controller’s touch-screen display.

Nintendo also said the ability to watch Amazon, Hulu and Netflix content on the Wii U won’t be available for a few more weeks. These are separate apps, though the content services will also be available through the Wii U app.

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New Variety owner Jay Penske slashes one-quarter staff

LOS ANGELES (TheWrap.com) – Jay Penske, the new owner of Variety, laid off nearly a quarter of the company’s staff on Thursday.

Between 20 and 25 employees from the struggling Hollywood trade’s circulation, database and conference departments were laid off. The editorial staff was not affected. Variety had about 120 employees before Thursday’s cuts.

“Without a doubt, this is a challenging day, and I particularly wanted to notify and acknowledge those of you who will be saying goodbye to valued colleagues and friends,” Penske, the CEO of Penske Media Corporation wrote in a memo obtained by the industry blog Deadline, which he also owns. “As we look ahead, Variety’s business holds almost limitless potential and I will remain available to answer any questions you might have regarding today’s changes and our future.”

Penske bought the paper last month at the fire-sale price of $ 25 million. In his memo, Penske said that he planned to invest in the editorial and digital departments while trimming the database services and business branch.

The jobs eliminated came from the LA411 and NY411 units – directories for production resources – and its administration and conference units, according to the memo. Deadline said that the cuts totaled 20 to 25 employees.

He also cut circulation staff, in what may presage a move to cut back on the paper’s printing schedule. Variety currently prints daily during the week and a weekly edition on Friday.

TheWrap previously reported that Penske planned to maintain the print edition and drop the paywall that blocked non-subscribers from reading Variety’s site, placing it in direct competition with competitors like the Hollywood Reporter, TheWrap and its corporate sister Deadline. The paywall has since been torn down.

Neither Penske nor Variety returned calls or emails from TheWrap requesting comment.

Here’s the full memo:

Dear Team

For the past six months, we have diligently reviewed every aspect of the Variety business. And in more recent weeks, we have outlined to Variety senior management an exciting and also aggressive trajectory for the brand’s resurgence. These steps will include substantial further investment in editorial and digital, but will unfortunately require some immediate eliminations in the following business units: LA411/NY411, Circ, Systems, Conferences, and Admin.

Without a doubt, this is a challenging day, and I particularly wanted to notify and acknowledge those of you who will be saying goodbye to valued colleagues and friends. As we look ahead, Variety’s business holds almost limitless potential and I will remain available to answer any questions you might have regarding today’s changes and our future. As always, please don’t hesitate to reach out to me, or see Tammy Chase to arrange an appointment.

Sincerely,

Jay Penske

CEO

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U.S. gives states another month to meet health exchange deadline

WASHINGTON (Reuters) – The Obama administration on Thursday gave states an extra month to say whether they plan to operate their own health insurance exchanges, after governors asked for more time in light of the November 6 election, which ensured the survival of Obama’s healthcare overhaul.

For the second time in six days, U.S. Health and Human Services Secretary Kathleen Sebelius extended deadlines relating to the exchanges. On Thursday she sent a letter to governors telling them that states would now have until December 14 to tell her department if they plan to set up an exchange.

The deadline for a letter of intent was originally set for midnight on Friday. Last week Sebelius told governors they would have until December 14 to file a blueprint showing how their exchanges would operate.

“While receiving a letter of intent now will help us assist states in finalizing their application, a state may submit both a letter of intent and an application to operate its own exchange by December 14,” Sebelius said in a letter to Republican governors.

“States may also apply to operate their exchange in partnership with the federal government by February 15, 2013. And a state may apply at any time to run an exchange in future years,” she wrote.

The extensions are seen as concessions to dozens of states that delayed compliance with the Patient Protection and Affordable Care Act until after the November 6 election, which President Barack Obama won. Opponents of the plan had hoped a victory for Republican Mitt Romney would ultimately result in the law’s repeal.

After Obama’s victory, states needed more time to prepare for exchanges, which are complex marketplaces meant to offer working families private insurance at federally subsidized rates beginning in 2014.

“We are confident governors will have enough time to decide whether they want to establish an exchange, work in partnership with the federal government or have a federally facilitated exchange in their state,” Sebelius wrote in the letter.

(Reporting by Deborah Charles; Editing by Lisa Shumaker)

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BP agrees to record criminal penalties for U.S. oil spill

NEW ORLEANS/WASHINGTON (Reuters) – BP Plc will pay $ 4.5 billion in penalties and plead guilty to felony misconduct in the Deepwater Horizon disaster, which caused the worst U.S. offshore oil spill ever.

U.S. Attorney General Eric Holder called the deal a “critical step forward” but was adamant that it did not end the criminal investigation of the 2010 spill.

The settlement announced on Thursday includes a $ 1.256 billion criminal fine, the largest such levy in U.S. history. It was not, however, the “global” settlement some had hoped for, which would have also resolved the considerable federal civil claims against the company at the same time.

“BP lied to me. They lied to the people of the Gulf. And they lied to their shareholders, and they lied to all Americans,” said Representative Ed Markey, the top Democrat on the House Natural Resources Committee who led investigations at the time of the spill.

The government also indicted the two highest-ranking BP supervisors aboard the Deepwater Horizon during the disaster, charging them with 23 criminal counts including manslaughter. One man’s lawyer said his client was being turned into a scapegoat for the disaster.

The April 2010 explosion on the rig in the Gulf of Mexico killed 11 workers. The mile-deep Macondo oil well then spewed 4.9 million barrels of oil into the Gulf over 87 days, fouling shorelines from Texas to Florida and eclipsing in severity the 1989 Exxon Valdez spill in Alaska.

The company said it would plead guilty to 11 felony counts related to the workers’ deaths, a felony related to obstruction of Congress and two misdemeanors. It also faces five years’ probation and the imposition of two monitors who will oversee its safety and ethics for the next four years.

Wall Street analysts said the deal will allow BP to focus again on oil production, while one U.S. senator from Louisiana said he hoped the settlement would not prevent his state and others from collecting civil penalties.

Investors shrugged off the news, and BP shares listed in New York and London were little changed on the day.

“It certainly is an encouraging step,” said Pavel Molchanov, oil company analyst with Raymond James. “By eliminating the overhang of the criminal litigation, it is another step in clearing up BP’s legal framework as it relates to Macondo.”

The disaster has dragged BP from second to a distant fourth in the ranking of top Western oil companies by value.

‘CRIMINAL SCALP’

“With these unprecedented criminal penalties assessed, I urge the Obama administration to be equally aggressive in securing civil monies that can help save our Louisiana coast” through other avenues, Louisiana Senator David Vitter said in a statement. “I certainly hope they didn’t trade any of those monies away just to nail this criminal scalp to the wall.”

Larry Schweiger, president of the National Wildlife Federation, called the settlement a “good down payment” on what BP should ultimately pay, which the environmental group argues is tens of billions of dollars more.

BP said the payments would be spread over six years, and that it expected to be able to handle the payments “within BP’s current financial framework.”

The company has sold $ 35 billion worth of assets to fund the costs of the spill. Matching that, it has paid $ 23 billion already in clean-up costs and claims, and has a further $ 12 billion earmarked for payment in its spill trust fund.

The oil company said it has not been advised of any government authority that intends to debar BP from federal contracting activities as a result of the deal.

‘RECKLESS MANAGEMENT’

The lawyers for Bob Kaluza, the BP well manager aboard the rig who faces manslaughter charges, condemned the case against the four-decade oilfield veteran.

“Bob was not an executive or high-level BP official. He was a dedicated rig worker who mourns his fallen co-workers every day,” Shaun Clarke and David Gerger said in a statement.

Kaluza faces two kinds of charges related to the workers’ deaths: Involuntary manslaughter, a broad statute covering individuals whose reckless disregard leads directly to loss of life; and seaman’s manslaughter, reserved for those employed on ships whose misconduct results in death.

As for BP, its settlement does not resolve civil litigation brought by the U.S. government and U.S. Gulf Coast states, which could be considered when the case convenes in February 2013.

Alabama Attorney General Luther Strange, who represents other spill-hit states in the case, said he intends to prove that BP’s actions were grossly negligent – a charge that would bring billions of dollars in extra liability if upheld. Louisiana Governor Bobby Jindal agreed in a statement.

“The majority of BP’s liability remains outstanding and we will hold them fully accountable,” he said.

Holder said at a news conference to discuss the criminal settlement that while the government and BP had held talks to resolve the civil claims, the sides had not been able to agree on a “satisfactory” number. He said a deal was still possible but the government was moving ahead to the February trial.

Negligence is a key issue. A gross negligence finding could nearly quadruple civil damages owed by BP under the Clean Water Act to $ 21 billion.

Chief Financial Officer Brian Gilvary said the company’s provisions should be enough to cover liabilities, provided it avoids a conviction for gross negligence, and that it had shareholder support to fight the case should that happen.

“I can boldly defend where we are in the provisions today. If something were to happen in the trial that read across to gross negligence … then we would certainly take that to appeal,” he said on a conference call with analysts.

Still unresolved is potential liability faced by Swiss-based Transocean Ltd, owner of the Deepwater Horizon vessel, and Halliburton Co, which provided cementing work on the well that U.S. investigators say was flawed.

Halliburton said it “remains confident that all the work it performed with respect to the Macondo well was completed in accordance with BP’s specifications for its well construction plan and instructions. Halliburton has cooperated with the DOJ’s investigation.” Transocean was not available for comment.

According to the Justice Department, errors made by BP and Transocean in deciphering a pressure test of the Macondo well are a clear indication of gross negligence.

Transocean disclosed in September that it is in discussions with the Justice Department to pay $ 1.5 billion to resolve civil and criminal claims.

BP has already announced an uncapped class-action settlement with private plaintiffs that the company estimates will cost $ 7.8 billion to resolve litigation brought by over 100,000 individuals and businesses claiming economic and medical damages from the spill.

(Additional reporting by Chris Baltimore and Anna Driver in Houston, Braden Reddall in San Francisco, Roberta Rampton in Washington, Verna Gates in Birmingham, Ala. and Andrew Callus in London; Writing by Ben Berkowitz; Editing by Edward Tobin, David Gregorio, Richard Chang and Tim Dobbyn)

Business News Headlines – Yahoo! News

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France urges Mali to step up talks with rebels

PARIS (AP) — France‘s president called Thursday for stepped-up talks between Mali’s government and any leaders from its breakaway north “who reject terrorism,” even as African nations geared up for a possible military operation against Islamic extremists there.

President Francois Hollande‘s comments suggested a growing openness to dialogue with the extremists, but he remained committed to supporting the military planning effort.

Northern Mali fell to Islamic extremists in April, after coup leaders toppled the government in Bamako, Mali‘s capital. Fearing that northern Mali could become the latest hotbed of terrorism, France has been a driving force in international efforts to bolster Mali’s army to drive the Islamists from power.

Hollande spoke with interim Mali President Dioncounda Traore by phone on Thursday, partly to detail European efforts to help strengthen Mali’s army.

In recent days, representatives from the most moderate of three al-Qaida-linked groups that control northern Mali have been meeting with Burkina Faso‘s president, appointed as a mediator.

“France reiterates its wish that political dialogue will intensify between Malian authorities and representatives of northern populations who reject terrorism,” Hollande’s office said in a statement. “The acceleration of this dialogue must accompany the progress in African military-planning efforts.”

Earlier this week, the African Union approved a plan that calls for 3,300 African troops to be deployed in order to win back Mali’s north. European countries including France and Germany have expressed a willingness to provide military trainers and logistics support, but have stopped short of committing combat troops.

France, like many European countries, fears that the arid, northern Sahel region of Mali could become a breeding ground for terrorism, where al-Qaida and its allies could plot hostage-takings and attacks in Europe or beyond.

France has millions of people whose families hail from former French colonies in north and west Africa. Authorities have long been concerned that French-born militants could travel abroad for terrorism training and return home later to possibly carry out attacks.

French authorities are already investigating two French citizens who were arrested in Mali and neighboring Niger and are suspected of seeking to join up with the al-Qaida-linked extremists, a judicial official told The Associated Press.

Ibrahim Ouattara, a 24-year-old native of the northern Paris suburb of Aubervilliers who has dual French and Malian nationality, was arrested inside Mali this month and remains in custody there, the official said.

Separately, a 27-year-old Frenchman was arrested in August in Niger and has since been handed over to authorities in France, the official said, speaking on condition of anonymity because she was not authorized to discuss terrorism cases publicly.

Europe News Headlines – Yahoo! News

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Sina’s profit beats on Weibo; co forecasts weak 4th-quarter revenue

(Reuters) – Chinese internet company Sina Corp eked out a profit in the third quarter that beat analysts’ estimates as strong advertising sales on its microblogging platform offset weaker website advertising but it forecast current-quarter revenue below expectations.

Shares of the company fell 6 percent to $ 49.72 in extended trading. They closed at $ 53.10 on the Nasdaq on Thursday.

Sina expects adjusted net revenue to range between $ 132 million and $ 136 million in the fourth quarter, with advertising revenues forecast to increase between 6 percent and 8 percent from a year earlier.

Analysts on average were expecting revenue of $ 151.9 million, according to Thomson Reuters I/B/E/S.

Sina, which makes most of its revenue from online advertising both on its website and through its microblogging platform, Weibo, is facing stiff headwinds this year as firms slash advertising budgets due to a worsening economic outlook.

Analysts said the spat between Japan and China over a few uninhabited islands in the East China Sea may have affected Sina’s website advertising sales as Japanese automakers cut back on advertising in China.

Net profit was $ 9.9 million for the September quarter, compared to a loss of $ 336.3 million a year earlier. The profit beat analysts’ expectations of $ 7.5 million.

Sina’s advertising revenue rose 19 percent to $ 120.6 million in the third quarter, while non-advertising revenue rose 9 percent to $ 31.8 million. Overall net revenue was $ 152.4 million, up from $ 130.3 million, a year earlier.

The company started monetizing Weibo by offering special services to business accounts and selling VIP memberships to regular users earlier this year.

Weibo contributed about 10 percent to total advertising revenue in the second quarter and had 368 million registered accounts.

(Reporting By Melanie Lee in Shanghai & Aurindom Mukherjee in Bangalore; Editing by Sriraj Kalluvila)

Internet News Headlines – Yahoo! News

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French mayor ends hunger strike after crisis aid

PARIS (Reuters) – A French mayor who went on hunger strike a week ago to demand emergency aid for his town ended his protest on Thursday and packed up the tent he had been sleeping in outside parliament after the government met his demands.

“I regret that things came to that but it was necessary,” Stephane Gatignon, mayor of Sevran, a poor town on the outskirts of Paris, told Reuters.

Gatignon slept six nights on the pavement outside the National Assembly to press his demand for 5 million euros ($ 6.4 million) of rescue aid, saying the economic crisis was pushing Sevran and dozens of other poor towns to the brink of ruin.

France’s cash-strapped government is seeking to slash its deficit in line with broader efforts to end a debt crisis that has plagued Europe for three years.

While the government is urging local authorities to do their part, it will increase aid to many of the poorest towns next year in a budget package that the lower house of parliament approved this week.

Gatignon said the government had indicated it was willing to deploy those funds in a way that would satisfy his demands. The office of urban affairs minister Francois Lamy did not respond to requests for comment.

The Sevran mayor looked weary but relieved after six days of consuming nothing but sugary tea.

“Today it’ll be a bit of broth, then some soup and slowly back to normal eating,” Gatignon said.

(Reporting by Emile Picy and Brian Love; Editing by Sonya Hepinstall and Robin Pomeroy)

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First Person: Key to Quitting Smoking — for Me at Least — Was Self-Hypnosis

Nov. 15 marks this year’s Great American Smokeout, when organizations across the country encourage smokers to quit the habit. Yahoo asked former smokers to offer to advice to those trying to stop smoking.

FIRST PERSON | Why I ever started smoking cigarettes in the first place, I’ll never know. Maybe it was peer pressure, maybe I thought it was cool or maybe I just wanted to act like an adult.

Whatever the reason, I know now how stupid of a decision it was.

At the ripe old age of 11 years old, I had my first cigarette. By the time I was 13, I was a regular pack-a-day smoker.

Back then, it was easy for kids to get access to cigarettes. I’d buy them from unscrupulous store clerks, steal them from parents or buy them out of cigarette machines at the local laundry mat. Thank goodness it’s a lot tougher for kids to get them today.

Smoking cigarettes became easier and easier, and before I knew it, I was hooked. I always knew they were bad for me, but quitting smoking was tougher than anything I had ever done before. About every two to three years, I’d try to quit and it would last for a few months at best. I finally gave up trying to quit in my mid 20s, figuring that I could never beat the habit.

By the time I hit my 30s, my bad habits were catching up with me. By then, I was smoking two packs a day and working construction full-time. Whenever I had to do something really strenuous, I’d get winded and have to take a break to catch my breath. After a pathetic foot-race loss to an uncle who was 20 years my senior, I knew it was time to give it up.

So how did I quit? Did I chew nicotine gum, wear a patch or take medications? Absolutely not. I quit the old-fashioned way. I just stopped smoking.

I used a technique that my grandfather had used years ago to help him quit smoking: self-hypnosis. Every day for an entire month, every time I lit a cigarette, I would tell myself how gross they tasted. I’d repeat the mantra to myself with every cigarette: “These cigarettes taste like crap.” Each cigarette soon got less and less flavorful.

By the end of the month, I had a pack of cigarettes that was half full and I was smoking just a few cigarettes a day. In about 45 days, I couldn’t even stand the smell of them. I didn’t even finish the last pack; I just tossed them in the garbage and never looked back. While not all of us might not be that strong-willed (or easily fooled), everyone can quit if they just put their mind to it.

Seniors/Aging News Headlines – Yahoo! News

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Chinese Communist Party to unveil new leadership

BEIJING (Reuters) – China‘s ruling Communist Party unveils a new leadership line-up on Thursday to steer the world’s second-largest economy for the next five years, with Vice President Xi Jinping taking over from outgoing President Hu Jintao as party chief.

The new members of the Politburo Standing Committee – the innermost circle of power in China’s authoritarian government – will emerge around 0300 GMT (10 p.m. EDT on Wednesday) after a closely controlled vote by the party’s new 205-member central committee, which was installed at the end of a five-yearly party congress on Wednesday.

Only Xi and Vice Premier Li Keqiang are certain to be on the new standing committee. Xi will take over Hu’s state position in March at the annual meeting of parliament, when Li will succeed Premier Wen Jiabao.

The committee is expected to be reduced to seven seats from nine to make consensus-building easier.

The other preferred candidates, according to sources close to the party leadership, are North Korean-trained economist Zhang Dejiang, financial guru Wang Qishan, minister of the party’s organization department Li Yuanchao, Tianjin’s party boss Zhang Gaoli, and the conservative Liu Yunshan, who has kept domestic media on a tight leash.

The list of the conservative-leaning preferred candidates was drawn up by Xi, Hu and Hu’s predecessor, Jiang Zemin, the sources said.

Wang, currently vice-premier in charge of economic affairs, is popular with foreign investors but seems set to lead the fight against corruption, having been elected to the party’s main anti-graft body on Wednesday.

Guangdong’s reform-minded party boss Wang Yang, Shanghai party boss Yu Zhengsheng and Liu Yandong, the lone woman, are dark horse candidates.

All eight of these people were on the list for the new central committee, the largest of the party’s top decision-making bodies. Exclusion from that committee means a person cannot progress to the Politburo or the standing committee.

The new leadership will emerge on Thursday morning to “meet the press” in a room in the cavernous, Soviet-style Great Hall of the People, which has been decked out in enormous red flags.

Intense secrecy has also surrounded who and how many will be promoted to the Politburo, a council of 20-odd members, and the all-powerful standing committee.

The composition of the two elite bodies could give clues to China’s political and economic direction, especially if they end up being dominated by conservatives.

Advocates of reform are pressing Xi to cut back the privileges of state-owned firms, make it easier for rural migrants to settle in cities, fix a fiscal system that encourages local governments to live off land expropriations and, above all, tether the powers of a state that they say risks suffocating growth and fanning discontent.

With growing public anger and unrest over everything from corruption to environmental degradation, there may also be cautious efforts to answer calls for more political reform, though nobody seriously expects a move towards full democracy.

The party could introduce experimental measures to broaden inner-party democracy – in other words, encouraging greater debate within the party – but stability remains a top concern and one-party rule will be safeguarded.

Another decision to watch will be chairman of the Central Military Commission. Hu may or may not choose to stay on in that post for a year or two, as did his predecessor, Jiang.

Which standing committee member gets which portfolio depends, in this hierarchical and top-down state, on the order members appear for the first time together on stage.

While the first person out will be Xi, signifying his position as party leader and president-designate, the party’s second-ranked position is head of the largely rubber stamp parliament, leaving the premier in third place.

But portfolios of the second and third-ranked leaders are likely to be reversed, giving Li higher status, sources have said.

Fourth position has historically been occupied by the head of the ceremonial advisory body to parliament, while fifth could be either vice president or propaganda tsar, sixth the executive vice premier and seventh the person in charge of fighting graft.

One position almost certain to go is that held by Zhou Yongkang, the domestic security tsar, reflecting fears the role has become too powerful.

(Additional reporting by Benjamin Kang Lim; Editing by Nick Macfie and Raju Gopalakrishnan)

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Egypt recalls envoy to Israel after Gaza strike

CAIRO (AP) — Egypt has recalled its ambassador to Israel after an Israeli airstrike killed the military commander of Gaza‘s ruling Hamas.

In a statement read on state TV late Wednesday, spokesman Yasser Ali said that President Mohammed Morsi recalled the ambassador and asked the Arab League‘s Secretary General to convene an emergency ministerial meeting in the wake of the Gaza violence.

Morsi also called for an immediate cease fire between Israel and Hamas, an offshoot of Morsi’s Muslim Brotherhood. Israel says it struck in response to rocket attacks from Gaza.

Hours earlier, Morsi’s Muslim Brotherhood group denounced the Israeli airstrike as a “crime that requires a quick Arab and international response to stem these massacres.”

Relations between Israel and Egypt have deteriorated since longtime President Hosni Mubarak was ousted last year.

Middle East News Headlines – Yahoo! News

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Android 4.2 For Nexus 7, Galaxy Nexus Now Available

When Google’s Nexus 10 tablet was unveiled recently, it was running Android 4.2, a new version which adds several features. That version is coming to your Nexus 7 or Galaxy Nexus device as well. Here’s what Android 4.2 brings, where to get it, and which Nexus devices are missing out.

​New features in Android 4.2

Mashable’s Christina Warren has the scoop on what Android 4.2′s bringing. Flashy additions include Daydream, a sort of screensaver for your smartphone or tablet, and Photo Sphere, a new way to take panoramic photographs that capture the whole world around you. Right now you can only see Photo Sphere images on Google+ or in Google Maps, but according to David Ruddock of the Android Police blog Google has made it so “Anyone could, in theory, build a Photo Sphere viewer.”

Less immediately noticeable improvements include a Swype-style gesture keyboard, where you don’t need to type individual letters, and a feature that lets multiple people share the same Android tablet without their apps and things getting in each others’ way. You’ll also be able to mirror your Android device’s screen on your HDTV, Apple AirPlay style, although instead of an Apple TV box you’ll need a third-party wireless display adapter.

​Who’s getting the upgrade now

Nexus 7 owners are already beginning to receive the Android 4.2 upgrade over the air. Your tablet will automatically check for it every so often, but if you want to hurry it along you can go to Settings -> About tablet -> System updates, and tell it to check again. You can also download it from Google and manually install it using Liam Spradlin’s instructions, although this is not recommended unless you’re an experienced Android hacker and are using the Wi-Fi version of the Nexus 7.

Galaxy Nexus owners who bought their phones from a wireless carrier have had to wait an unusually long time for upgrades, as long as several months after a new Android version’s announced. If you bought your Galaxy Nexus phone from a wireless carrier, an upgrade probably won’t be available anytime soon. People who purchased their Galaxy Nexus from the Google Play store are reporting that they are getting the upgrade, though, and Spradlin again has instructions for how to install manually if you are using a Galaxy Nexus bought from the Google Play store.​

Who’s being left out

While announcing that Android 4.2′s programming code was being released to the Android Open-Source Project, Google rep Jean-Baptiste Queru said “There is no support for 4.2 on Nexus S and Xoom.” The Nexus S was a Nexus smartphone released about two years ago, in late 2010, while the Motorola Xoom was the first tablet released (in early 2011) running the Honeycomb version of Android. The Xoom was not an official Nexus device, but was also made in close partnership with Google, and showcased the latest Android software.

Both devices received upgrades to Android 4.1, the first Jelly Bean version. It looks like this is where the upgrade train ends for them, though, after almost two years of support. In contrast, Apple’s iPhone 3GS, released in mid-2009, just recently received an upgrade to the latest version of iOS.

Jared Spurbeck is an open-source software enthusiast, who uses an Android phone and an Ubuntu laptop PC. He has been writing about technology and electronics since 2008.

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NBC names new “Today” show chiefs

(Reuters) – Comcast‘s NBC has appointed two executives to take charge of the “Today” show, a day after the television network announced that longtime producer Jim Bell would be leaving to take a larger role in the sports division.

Don Nash, a broadcast producer who has worked on NBC’s morning show for 23 years, will become the executive producer, reporting to Alexandra Wallace, who has been named executive in charge of the show.

The reshuffling is part of NBC efforts to revive the “Today” show, which has been in a back-and-forth ratings war with ABC’s “Good Morning America” ever since ABC snapped NBC’s 16-year unbeaten streak earlier in the year.

“Today” is one of NBC’s most profitable TV shows, generating $ 485 million in ad revenues in 2011, up 6.6 percent from 2010, according to Kantar Media, which provides data to advertisers. Rival “Good Morning America” took in $ 299 million last year.

NBC said on Tuesday that former executive producer Bell would be leaving the morning show to become a full-time executive producer of the Olympics. The network has a contract to broadcast the Olympics in the United States for the next four games in Russia, Brazil, South Korea and an unnamed host city in 2020.

Bell, who has headed the show since 2005, was blamed this year for the controversial firing of Ann Curry as anchor alongside Matt Lauer.

Reuters had previously reported in August that Bell was in line for a kind of uber-producing sports role like the one Dick Ebersol – NBC’s longtime Olympics executive producer and former sports chief who served as a mentor to Bell – played for the network.

(Reporting By Liana B. Baker; Editing by Tim Dobbyn)

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Black patients fare worse with kidney cancer: study

NEW YORK (Reuters Health) – White patients with the most common form of kidney cancer, called renal cell carcinoma, are slightly more likely to survive the disease than black patients, according to a large new study.

The researchers looked at nearly 40,000 cases and found that black patients tend to start out with more favorable types of renal carcinomas, but “despite that, we still see poorer survival among African Americans,” said Wong-Ho Chow, the lead author of the study and a professor at the University of Texas MD Anderson Cancer Center.

It’s been known that blacks have higher rates of renal cancer than whites, and smaller studies have also pointed to racial disparities in how patients make out after their diagnosis. But experts have disagreed on the reasons.

About 64,000 people will be diagnosed with some type of kidney cancer this year in the U.S., according to the National Cancer Institute, making the disease the number 12 cause of cancer deaths for Americans.

Chow and her colleagues looked to a large national database to confirm whether African Americans fare worse with renal cell carcinoma and to look for any clues to why that might be the case.

The researchers collected information on 39,350 patients – 4,359 of whom were black and 34,991 white – diagnosed with renal cell carcinoma from 1992 to 2007.

They found that 72.6 percent of white patients survived at least five years out from their diagnosis, while 68 percent of blacks lived for at least five years.

Chow’s group reports in the medical journal Cancer that 66.7 percent of black patients and 61.9 percent of whites were diagnosed with tumors that had not yet spread.

“It wasn’t related to cancers being diagnosed at a later stage,” said Dr. Charles Modlin, the director of the Minority Men’s Health Center at the Cleveland Clinic’s Glickman Urological Institute, who was not involved in the study. “African Americans were more likely to be diagnosed when tumors were smaller, more localized.”

In addition, a greater proportion of black patients had a less dangerous type of renal cell carcinoma than white patients, “and still they didn’t do as well,” Modlin pointed out.

“I’m thinking maybe it has something to do with the type or quality of care that they receive,” he told Reuters Health.

Survival rates were much lower, and equally so, among both black and white patients who did not have surgery to remove their tumors. But whereas 10.5 percent of white patients got no surgery, 14.5 percent of black patients did not have surgery, the study found.

It’s also possible there could be underlying health conditions more common among blacks that predispose them to a worse outcome, researchers said.

“We know African Americans are more prone to hypertension, which, by the way, is a risk factor for renal cell cancer,” said Chow.

But, she added, information on how many people had hypertension was not in this dataset.

“At this point we don’t have the data to explain (the study findings) yet,” Chow said.

Another unknown that could have influenced the outcomes, Chow told Reuters Health, is whether some patients might have made lifestyle changes, such as losing weight or quitting smoking, after their diagnosis, but she wasn’t able to get that information either.

She added that until doctors have a better understanding of what’s driving this disparity, there’s not much advice to offer with regard to treating patients.

Modlin said it’s important to at least be aware of these disparities.

“Because one thing we see is that healthcare providers are not really aware or don’t take into consideration that these health care disparities are real and (are) significant problems,” he said.

SOURCE: http://bit.ly/ZCl7Y4 Cancer, online November 12, 2012.

Diseases/Conditions News Headlines – Yahoo! News

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Best Buy CEO sets goals; Wall Street begs for more details

(Reuters) – Best Buy Co Inc hopes to triple its operating margins over time, the company said on Tuesday, though investors and analysts were left wanting for details on how – and how soon – the new chief executive would turn around the world’s largest consumer electronics chain.

The aggressive new targets come as Best Buy faces cut-throat competition from online and discount retailers like Wal-Mart Stores Inc and Amazon.com Inc .

CEO Hubert Joly got a difficult reception at an investor day in New York, as people questioned whether management was focusing too much on wringing higher sales out of existing customers rather than attracting new ones. Joly was named CEO on August 20.

“I still think I am a little bit mixed on digesting the take-aways of the presentation. I think they said a lot of good things, but I think people were looking for a little bit more of a playbook and the next steps,” said John Tomlinson, an analyst with ITG Investment Research, in New York. “There’s a lot of pieces to the fixing story that seemed a little opaque and vague.”

Best Buy’s stock closed nearly 1 percent lower at $ 15.70 on Tuesday, continuing a slide that has knocked off a third of the company‘s market capitalization this year. The stock touched a 10-year low of $ 14.39 a week ago.

Dimitri van Toren, senior portfolio manager at Dutch asset manager Syntrus Achmea, which holds about 200,000 Best Buy shares, said he was worried about structural issues and a “management vacuum” at the retailer, but that he would stay in the stock despite concerns about the upcoming holiday season.

The meeting took place against the backdrop of a potential buyout offer from founder and former CEO Richard Schulze, who is expected to make an offer as soon as next month.

“I spend no time worrying about what our corporate structure will be,” Joly told reporters after the event. “I tend to focus on decisions I can influence rather than decisions I can’t influence.”

A representative for Schulze did not immediately respond to a request seeking his thoughts on Joly’s plan.

Joly said “it would have been ridiculous” to offer more concrete details after only a few weeks on the job. He said this meeting was more about setting the record straight and reassuring investors about the company’s future.

“The perception was that Best Buy was dying,” Joly said.

MARGIN TARGETS

In a statement on Tuesday, the company said its short-term goal will be “to stabilize and then begin increasing its comparable-store sales and operating margin.” Over time, it is aiming for a return on invested capital of 13 percent to 15 percent, in addition to a 5 percent to 6 percent operating margin target.

In the last fiscal year, Best Buy had an operating margin of about 2.1 percent. The last time that margin exceeded 5 percent was in the fiscal year that ended in early 2008.

Joly said a mixture of excessive costs and price competition hurt margins, and that the retailer would turn to a wider variety of higher-margin, private-label products to boost results. One example is the company’s own Insignia-brand electronics.

Best Buy has been struggling to combat a phenomenon known as “showrooming,” where people visit its stores to look at products and then buy them online for less.

Joly acknowledged the company has suffered from a “price perception issue” among customers that it needed to address, as well as weakness in its online operations.

The head of the company’s digital business said its online conversion rate – which measures how successfully Best Buy translates customer visits into actual sales – was only about half of what it should be.

“Many of these problems are a result of our own making,” Joly said during the investor presentation.

HOLIDAYS COMING

Best Buy also said on Tuesday that it would pursue a plan to “optimize its store footprint on an ongoing basis,” which suggested the company may look at ways to shrink or close stores, as some other big-box retailers have done. In late March, the company said it would close 50 large U.S. stores.

Joly warned that merely closing stores would not boost operating income, as most of the big-box stores are already profitable. Relocation to smaller space may be an option, however; he said 71 percent of the large-format stores have leases expiring within the next six years.

The details of Joly’s long-awaited plan came roughly a week before the unofficial start of the year’s biggest selling season.

The retailer, which has posted declines in same-store sales in eight of the last nine quarters, warned last month it expected earnings and same-store sales to fall again in the third quarter.

“I am already sick and tired of negative comps,” Joly said, referring to same-store sales figures.

The CEO also admitted a number of past investments have not paid off and promised the new leadership would be “prudent” about that in the future, a nod to Wall Street’s lingering concerns about spending by past management.

(Reporting by Dhanya Skariachan in New York; Writing by Ben Berkowitz; Editing by Maureen Bavdek, Phil Berlowitz, Matthew Lewis and Jan Paschal)

Business News Headlines – Yahoo! News

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General investigated for emails to Petraeus friend

PERTH, Australia (AP) — In a new twist to the Gen. David Petraeus sex scandal, the Pentagon said Tuesday that the top American commander in Afghanistan, Gen. John Allen, is under investigation for alleged “inappropriate communications” with a woman who is said to have received threatening emails from Paula Broadwell, the woman with whom Petraeus had an extramarital affair.

Defense Secretary Leon Panetta said in a written statement issued to reporters aboard his aircraft, en route from Honolulu to Perth, Australia, that the FBI referred the matter to the Pentagon on Sunday.

Panetta said that he ordered a Pentagon investigation of Allen on Monday.

A senior defense official traveling with Panetta said Allen’s communications were with Jill Kelley, who has been described as an unpaid social liaison at MacDill Air Force Base, Fla., which is headquarters to the U.S. Central Command. She is not a U.S. government employee.

Kelley is said to have received threatening emails from Broadwell, who is Petraeus’ biographer and who had an extramarital affair with Petraeus that reportedly began after he became CIA director in September 2011.

Petraeus resigned as CIA director on Friday.

Allen, a four-star Marine general, succeeded Petraeus as the top American commander in Afghanistan in July 2011.

The senior official, who discussed the matter only on condition of anonymity because it is under investigation, said Panetta believed it was prudent to launch a Pentagon investigation, although the official would not explain the nature of Allen’s problematic communications.

The official said 20,000 to 30,000 pages of emails and other documents from Allen’s communications with Kelley between 2010 and 2012 are under review. He would not say whether they involved sexual matters or whether they are thought to include unauthorized disclosures of classified information. He said he did not know whether Petraeus is mentioned in the emails.

“Gen. Allen disputes that he has engaged in any wrongdoing in this matter,” the official said. He said Allen currently is in Washington.

Panetta said that while the matter is being investigated by the Defense Department Inspector General, Allen will remain in his post as commander of the International Security Assistance Force, based in Kabul. He praised Allen as having been instrumental in making progress in the war.

The FBI’s decision to refer the Allen matter to the Pentagon rather than keep it itself, combined with Panetta’s decision to allow Allen to continue as Afghanistan commander without a suspension, suggested strongly that officials viewed whatever happened as a possible infraction of military rules rather than a violation of federal criminal law.

Allen was Deputy Commander of Central Command, based in Tampa, prior to taking over in Afghanistan. He also is a veteran of the Iraq war.

In the meantime, Panetta said, Allen’s nomination to be the next commander of U.S. European Command and the commander of NATO forces in Europe has been put on hold “until the relevant facts are determined.” He had been expected to take that new post in early 2013, if confirmed by the Senate, as had been widely expected.

Panetta said President Barack Obama was consulted and agreed that Allen’s nomination should be put on hold. Allen was to testify at his confirmation hearing before the Senate Armed Services Committee on Thursday. Panetta said he asked committee leaders to delay that hearing.

NATO officials had no comment about the delay in Allen’s appointment.

“We have seen Secretary Panetta‘s statement,” NATO spokeswoman Carmen Romero said in Brussels. “It is a U.S. investigation.”

Panetta also said he wants the Senate Armed Services Committee to act promptly on Obama’s nomination of Gen. Joseph Dunford to succeed Allen as commander in Afghanistan. That nomination was made several weeks ago. Dunford’s hearing is also scheduled for Thursday.

___

Associated Press writer Slobodan Lekic in Kabul, Afghanistan, contributed to this report.

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